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Hence the observed increase in GSH activity (total and reduced glutathione) in the magnesium treated diabetic animals may possibly be due to its effect on the enzymes gamma glutamyl transpeptidase (GGT), glutamate cysteine ligase and glutathione synthetase respectively

suggest that hyperglycemia-induced oxidative stress affects protease-activated receptor 2-mediated vasodilation in the endothelium through a NOX-triggered signaling cascade, which can be suppressed by SGLT2i (200)

MEAs recordings and analysis Recordings of neuronal electrophysiological activity were performed with 24-well MEAs (Multichannel systems) (24 independent wells with 12 embedded microelectrodes, 30 m in diameter and spaced 200 m apart) covered with a Breathe Easier sealing membrane (Sigma Aldrich)

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